have severe kidney problems, end stage renal disease, or are on dialysis.Talk to your healthcare provider about what you can do to prevent dehydration. You may be at higher risk of dehydration if you have kidney problems, are 65 years of age or older, are on a low salt diet, or take medicines to lower your blood pressure, including water pills (diuretics). Dehydration may cause you to feel dizzy, faint, light-headed, or weak, especially when you stand up. TRIJARDY XR can cause some people to become dehydrated (the loss of body water and salt). Stop taking TRIJARDY XR and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms, and, if possible, check for ketones in your urine:ĭehydration. Ketoacidosis has also happened in people with diabetes who were sick or who had surgery during treatment with TRIJARDY XR. Ketoacidosis occurs in people with type 1 diabetes and can also occur in people with type 2 diabetes taking TRIJARDY XR, even if blood sugar is less than 250 mg/dL. Ketoacidosis is a serious condition which needs to be treated in the hospital. Ketoacidosis (increased ketones in your blood or urine). The pain may happen with or without vomiting. The pain may be felt going from your abdomen through to your back. Stop taking TRIJARDY XR and call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe and will not go away. Before you start taking TRIJARDY XR tell your healthcare provider if you have ever had pancreatitis, a history of alcoholism, gallstones, or high triglyceride levels. Pancreatitis may be severe and lead to death. Inflammation of the pancreas (pancreatitis) is another serious side effect that can happen to people taking TRIJARDY XR. You have a higher chance of getting lactic acidosis with TRIJARDY XR if you: have moderate to severe kidney problems have liver problems drink alcohol (very often or short term “binge” drinking) get dehydrated (lose a large amount of body fluids) have x-ray tests that use injectable dye have surgery have congestive heart failure have a heart attack, severe infection, or stroke, or are 65 years of age or older. Stop taking TRIJARDY XR and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms of lactic acidosis: feel very weak and tired, have unusual muscle pain, have trouble breathing, have stomach or intestinal problems with nausea and vomiting, or diarrhea, feel sleepy or sleep longer than usual, feel cold in your arms and legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat. Lactic acidosis is a medical emergency and must be treated in a hospital. Metformin hydrochloride, one of the medicines in TRIJARDY XR, can cause lactic acidosis, a rare but serious condition that can cause death. Lactic acidosis (a buildup of lactic acid in the blood). Serious side effects can happen in people taking TRIJARDY XR, including: When linagliptin 5 mg alone was added, 36% of patients achieved an A1C below 7%. When they added empagliflozin 10 mg or 25 mg alone, 28% and 33% of patients achieved an A1C below 7%. This resulted in 58% of patients taking metformin, empagliflozin 10 mg, and linagliptin 5 mg achieving an A1C below 7% and 62% of patients taking metformin, empagliflozin 25 mg, and linagliptin 5 mg achieving an A1C below 7%. *In a 6-month study, 686 patients who were taking metformin with an A1C above 7% were given empagliflozin 10 mg along with linagliptin 5 mg or empagliflozin 25 mg along with linagliptin 5 mg.
You and your doctor will determine your personal A1C goals. In a study, 58% of people taking TRIJARDY XR with a baseline A1C above 7% (n=74) were able to achieve an A1C of less than 7.0.* This is a target suggested by the American Diabetes Association (ADA). Your A1C is an average of your blood sugar over 2–3 months, and an important measure of how your type 2 diabetes treatment is going. And in adults with type 2 diabetes who also have known heart disease, JARDIANCE, one of the medicines in TRIJARDY XR, can reduce the risk of cardiovascular death. TRIJARDY XR combines 3 diabetes medications-JARDIANCE (empagliflozin), TRADJENTA (linagliptin), and metformin hydrochloride, working together to lower A1C, along with diet and exercise. Type 2 diabetes can make it hard to control your A1C-it may be time for a medication that works in multiple ways. TRIJARDY XR contains the benefits of 3 medications: Learn more about TRIJARDY XR TRIJARDY XR can help lower your A1C If you have had pancreatitis (inflammation of the pancreas) in the past, it is not known if you have a higher chance of getting pancreatitis while you take TRIJARDY XR.
It may increase their risk of diabetic ketoacidosis (increased ketones in the blood or urine). 3-in-1 TRIJARDY XR may give you a chance of lowering your A1C
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